湖南师范大学自然科学学报

2020, v.43;No.183(04) 56-62

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

西黄胶囊减少头颈部肿瘤放化疗副反应的回顾性对照研究
A Retrospective Controlled Study of Xihuang Capsule on Reducing Side Effects of Radiochemotherapy in Head and Neck Cancer

彭美玲;张瑶;李敏;卢晓云;刘劲;唐黎;符佳;范莎莎;段华新;
PENG Mei-ling;ZHANG Yao;LI Min;LU Xiao-yun;LIU Jin;TANG Li;FU Jia;FAN Sha-sha;DUAN Hua-xin;Department of Oncology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University;

摘要(Abstract):

为分析西黄胶囊对头颈部肿瘤放化疗副反应的作用,回顾2017年1月—2020年2月就诊于湖南省人民医院头颈部恶性肿瘤患者,筛选可入组的病例,并将其分为观察组(服用西黄胶囊)和对照组(非服用西黄胶囊)。对比两组辅助药物使用率及使用天数、骨髓抑制发生率,发现观察组雾化、强阿片类药物、肠外营养使用率低于对照组,观察组雾化、静脉激素使用平均时间低于对照组;观察组发生2~4级中性粒细胞减少(OR 0.230,95%CI 0.095~0.558,P=0.001)及2~4级血小板降低(OR 0.341,95%CI 0.137~0.847,P=0.02)较对照组减少。说明西黄胶囊能减少骨髓抑制的发生和严重程度,减少激素抗炎药物、强阿片类药物及肠外营养药物使用。
To study the effect of Xihuang capsules in reducing side effects of radiochemotherapy for head and neck tumors, in this work, patients diagnosed head and neck cancer in the Hunan Provincial People's Hospital from January 2017 to February 2020 were systematically assessed in this work. Based on the fact of whether Xihuang capsules were used or not, patients were divided into the observation group(Xihuang capsules used) and the control group(without Xihuang capsules usage). With the usage rate of adjuvant drugs, the number of usage days, and the occurrence of bone marrow suppression, we found that the observation group displayed lower usage rates of nebulization inhalation, opioids and parenteral nutrition than the control group. The observation group had lower average usage time for nebulization inhalation and intravenous hormone than the control group. The severe side effects of grade 2~4 neutral granules cytocytopenia(OR 0.230; 95%CI 0.095~0.558; P=0.001), grade 2~4 thrombocytopenia(OR 0.341; 95%CI 0.137~0.847; P=0.02) occurred less in the observation group than the control group. Based on these results, we conclude that Xihuang capsules can reduce the occurrence and severity of bone marrow suppression, and they could also reduce the application of intravenous hormone, parenteral nutrition, and opioids.

关键词(KeyWords): 西黄胶囊;头颈部肿瘤;放化疗;副反应
Xihuang capsule;head and neck cancer;radiochemotherapy;side effets

Abstract:

Keywords:

基金项目(Foundation): 湖南省中医药科研计划项目(2016139)

作者(Author): 彭美玲;张瑶;李敏;卢晓云;刘劲;唐黎;符佳;范莎莎;段华新;
PENG Mei-ling;ZHANG Yao;LI Min;LU Xiao-yun;LIU Jin;TANG Li;FU Jia;FAN Sha-sha;DUAN Hua-xin;Department of Oncology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University;

Email:

DOI:

参考文献(References):

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享